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Zinātniskās atsauces

LIVEO atsauces:

Zinātniski pierādīta efektivitāte

LIVEO sastāvā ir LGG® un BB-12® – pasaulē pētītākās probiotikas ar pierādītu efektivitāti.

Īstermiņa un ilgtermiņa iedarbība

https://pubmed.ncbi.nlm.nih.gov/?term=LGG+BB-12

Zarnu mikrobioms palīdz sagremot pārtiku, ražo vitamīnus un citas svarīgas vielas, kā arī aizsargā pret nelabvēlīgiem mikroorganismiem.

Ogunrinola GA, Oyewale JO, Oshamika OO, Olasehinde GI. The Human Microbiome and Its Impacts on Health. Int J Microbiol. 2020

Probiotikas ir dzīvi mikroorganismi, kas, lietoti pietiekošā daudzumā, sniedz labumu organismam.

Pasaules gastroenterologu vadlīnijas. Probiotikas un prebiotikas. https://www.worldgastroenterology.org/guidelines/probiotics-and-prebiotics

Līdzsvarots un veselīgs zarnu mikrobioms labvēlīgi ietekmē imunitāti, veicina infekciju profilaksi un normalizē gremošanas procesus.

Araos R, D’Agata EMC. The human microbiota and infection prevention. Infect Control Hosp Epidemiol. 2019

Dimidi E, Christodoulides S, Scott SM, Whelan K. Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation. Adv Nutr. 2017

Kho ZY, Lal SK. The Human Gut Microbiome – A Potential Controller of Wellness and Disease. Front Microbiol. 2018

LIVEO intime atsauces:

LIVEO intime pienskābo baktēriju komplekss sievietēm – tā sastāvā esošie baktēriju celmi RC-14® un GR-1® ir ar pierādītu klīnisko efektivitāti un labvēlīgu ietekmi uz sievietes maksts mikrofloru, ko apliecina virkne pētījumu.

Anukam K, Osazuwa E, Ahonkhai I, et al. Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial. Microbes Infect. 2006;8(6):1450-1454. doi:10.1016/j.micinf.2006.01.003

Homayouni A, Bastani P, Ziyadi S, et al. Effects of probiotics on the recurrence of bacterial vaginosis. J Low Genit Tract Di. 2014;18(1):79-86. doi:10.1097/lgt.0b013e31829156ec

Reid G, Bruce AW. Urogenital infections in women: can probiotics help? Postgrad Med J. 2003;79(934):428. doi:10.1136/pmj.79.934.428

Reid G, Charbonneau D, Erb J, et al. Oral use of Lactobacillus rhamnosus GR‐1 and L. fermentum RC‐14 significantly alters vaginal flora: randomized, placebo‐controlled trial in 64 healthy women. Fems Immunol Medical Microbiol. 2003;35(2):131-134. doi:10.1016/s0928-8244(02)00465-0

Vujic G, Knez AJ, Stefanovic VD, Vrbanovic VK. Efficacy of orally applied probiotic capsules for bacterial vaginosis and other vaginal infections: a double-blind, randomized, placebo-controlled study. Eur J Obstet Gyn R B. 2013;168(1):75-79. doi:10.1016/j.ejogrb.2012.12.031

Younes JA, Lievens E, Hummelen R, Westen R van der, Reid G, Petrova MI. Women and their microbes: the unexpected friendship. Trends Microbiol. 2018;26(1):16-32. doi:10.1016/j.tim.2017.07.008

 

Atsauces, kas izmantotas mājas lapas tekstos:

(1) Vlieger AM, Robroch A, van Buuren S, Kiers J, Rijkers G, Benninga MA, te Biesebeke R. Tolerance and safety of Lactobacillus paracasei ssp. paracasei in combination with Bifidobacterium animalis ssp. lactis in a prebiotic-containing infant formula: a randomised controlled trial. Br J Nutr. 2009 Sep;102(6):869-75. doi: 10.1017/S0007114509289069. Epub 2009 Mar 31. PMID: 19331702.

(2) Weizman Z, Asli G, Alsheikh A. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics. 2005 Jan;115(1):5-9. doi: 10.1542/peds.2004-1815. PMID: 15629974.

(3) Saavedra JM, Bauman NA, Oung I, Perman JA, Yolken RH. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet. 1994 Oct 15;344(8929):1046-9. doi: 10.1016/s0140-6736(94)91708-6. PMID: 7934445.

(4) Chen K, Zhang G, Xie H, You L, Li H, Zhang Y, Du C, Xu S, Melsaether C, Yuan S. Efficacy of Bifidobacterium animalis subsp. lactis, BB-12® on infant colic – a randomised, double-blinded, placebo-controlled study. Benef Microbes. 2021 Nov 16;12(6):531-540. doi: 10.3920/BM2020.0233. Epub 2021 Sep 22. PMID: 34550055.

(5) Eskesen D, Jespersen L, Michelsen B, Whorwell PJ, Müller-Lissner S, Morberg CM. Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutr. 2015 Nov 28;114(10):1638-46. doi: 10.1017/S0007114515003347. Epub 2015 Sep 18. PMID: 26382580; PMCID: PMC4657032.

(6) Eskesen D, Jespersen L, Michelsen B, Whorwell PJ, Müller-Lissner S, Morberg CM. Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutr. 2015 Nov 28;114(10):1638-46. doi: 10.1017/S0007114515003347. Epub 2015 Sep 18. PMID: 26382580; PMCID: PMC4657032.

(7) Pitkala KH, Strandberg TE, Finne Soveri UH, Ouwehand AC, Poussa T, Salminen S. Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial. J Nutr Health Aging. 2007 Jul-Aug;11(4):305-11. PMID: 17653486.

(8) Rizzardini G, Eskesen D, Calder PC, Capetti A, Jespersen L, Clerici M. Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study. Br J Nutr. 2012 Mar;107(6):876-84. doi: 10.1017/S000711451100420X. Epub 2011 Sep 7. PMID: 21899798.

(9) Isolauri E, Juntunen M, Rautanen T, Sillanaukee P, Koivula T. A human Lactobacillus strain (Lactobacillus casei sp strain GG) promotes recovery from acute diarrhea in children. Pediatrics. 1991 Jul;88(1):90-7. PMID: 1905394.

(10) Hojsak I, Snovak N, Abdović S, Szajewska H, Misak Z, Kolacek S. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clin Nutr. 2010 Jun;29(3):312-6. doi: 10.1016/j.clnu.2009.09.008. Epub 2009 Nov 5. PMID: 19896252.

(11) Näse L, Hatakka K, Savilahti E, Saxelin M, Pönkä A, Poussa T, Korpela R, Meurman JH. Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res. 2001 Nov-Dec;35(6):412-20. doi: 10.1159/000047484. PMID: 11799281.

(12)Pørksen CJ, Keller MK, Damholt A, Frederiksen AKS, Ekstrand KR, Markvart M, Larsen T, Bakhshandeh A. The effect of a lozenge combining prebiotic arginine and probiotics on caries increment in children during 10-12 months, a randomized clinical trial. J Dent. 2023 Aug;135:104599. doi: 10.1016/j.jdent.2023.104599. Epub 2023 Jun 24. Erratum in: J Dent. 2024 Feb;141:104807. doi: 10.1016/j.jdent.2023.104807. PMID: 37356561.

(13) Glavina D, Gorseta K, Skrinjarić I, Vranić DN, Mehulić K, Kozul K. Effect of LGG yoghurt on Streptococcus mutans and Lactobacillus spp. salivary counts in children. Coll Antropol. 2012 Mar;36(1):129-32. PMID: 22816209.

(14) Aggarwal S, Upadhyay A, Shah D, Teotia N, Agarwal A, Jaiswal V. Lactobacillus GG for treatment of acute childhood diarrhoea: an open labelled, randomized controlled trial. Indian J Med Res. 2014 Mar;139(3):379-85. PMID: 24820831; PMCID: PMC4069731.

(15) Sindhu KN, Sowmyanarayanan TV, Paul A, Babji S, Ajjampur SS, Priyadarshini S, Sarkar R, Balasubramanian KA, Wanke CA, Ward HD, Kang G. Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2014 Apr;58(8):1107-15. doi: 10.1093/cid/ciu065. Epub 2014 Feb 5. PMID: 24501384; PMCID: PMC3967829.

(16) Hojsak I, Abdović S, Szajewska H, Milosević M, Krznarić Z, Kolacek S. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics. 2010 May;125(5):e1171-7. doi: 10.1542/peds.2009-2568. Epub 2010 Apr 19. PMID: 20403940.

(17) Nocerino R, De Filippis F, Cecere G, et al. The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12 in infant colic: A randomised, double blind, placebo-controlled trial. Aliment Pharmacol Ther. 2020 Jan:51 (1):110-120. doi: 10.1111/apt.15561. Epub 2019 Dec 3. PMID: 31797399; PMCID: PMC6973258